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KMID : 1123920050190041050
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 4 p.1050 ~ p.1054
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Effects of Arsenic Compounds on the Induction of Apoptotic Cell Death in A549 Human Non-small Cell Lung Cancer Cells
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Choi Yung-Hyun
Choi Woo-Young
Choi Byung-Tae
Lee Yong-Tae
Lee Won-Ho
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Abstract
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Recently, arsenic compounds were considered as novel agents for treatment of acute promyelocytic leukemia and malignant tumors. However, it showed severe toxicity effect on normal tissue at the same time. In this study, to investigate the possible molecular mechanism (s) of arsenic compounds as candidate of anti-cancer drugs, we compared the abilities of two arsenic compounds, tetraarsenic oxide and arsenic trioxide (diarsenic oxide, ), to induce cell growth inhibition as well as apoptosis induction in A549 human non-small cell lung cancer cells. Both treatment declined the cell growth and viability of A549 cells in a concentration-dependent manner, which was associated with induction of G1 arrest of the cell cycle and apoptotic cell death. However, induced growth inhibition and apoptosis in A549 cells at much lower concentrations than down-regulated the levels of anti-apoptotic Bcl-2 protein, however, the levels of Bax, a pro-apoptotic protein, were up-regulated in a dose-dependent manner. In conclusion, might be a new arsenic compound which may induce apoptosis in A549 cells by modulation the Bcl-2 family and deserves further evaluation.
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KEYWORD
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arsenic compounds, A549, apoptosis, Bax
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